단삼표준화시료 PF2401-SF의 사염화탄소에 의한 간독성 보호기전
Protective Mechanisms of PF2401-SF, Standardized Fraction of Salvia miltiorrhiza, Against Carbon Tetrachloride-induced Hepatotoxicity
김웅현, 손동환, 이성희,
소속 상세정보
김웅현 ( Kim Woong-Hyun ) - 원광대학교 약학대학 약품연구소
손동환 ( Sohn Dong-Hwan ) - 원광대학교 약학대학 약품연구소
이성희 ( Lee Sung-Hee ) - 원광대학교 약학대학 약품연구소
KMID : 0829220120360050293
Abstract
We previously prepared a standardized and purified extract of Salvia miltiorrhiza, PF2401-SF, and showed that it protected
against hepatic injury more effectively than ethanol based extraction. In this study, we determined the hepatoprotective mechanisms of PF2401-SF in vivo. Hepatic injury was induced in mice by using carbon tetrachloride (CCl4). Treatment with PF2401-SF (1 or 10 mg/kg, p.o.) significantly reduced the levels of alanine transaminase (ALT) and aspartate transaminase (AST) in the plasma. PF2401-SF treatment resulted in further elevation of the CCl4-induced heme oxygenase-1 (HO-1) expression, which contributed to the PF2401-SF-mediated liver protection. Additionally, PF2401-SF treatment significantly reduced the c-Jun NH2-terminal kinase (JNK) phosphorylation induced by CCl4. Taken together, these results suggest that the protective effect of PF2401-SF, a standardized fraction of S. miltiorrhiza, against CCl4-induced hepatic injury in mice arises from its induction effect on HO-1 and inhibitory effect on JNK phosphorylation.
키워드
PF2401-SF; Heme oxygenase-1; c-Jun NH2-terminal kinase; Salvia miltiorrhiza; Hepatoprotection; Carbon tetrachloride
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